INTRODUCTION: A suite of human health and performance metrics can be used to provide a holistic cognitive, physical, and emotional view of an individual and assess how well they are integrated with the overall system during spaceflight missions. The combination of such individual metrics as defined here is notionally termed “crewmember operational state.” METHODS: This work identifies and defines the contributing components that comprise the proposed crewmember operational state. RESULTS: Considerations of how to measure the components in a spaceflight environment are summarized and the steps required to analyze and integrate these measurements into an operational framework are outlined. Use of the measurements and integration steps are then extended into several applications relevant to human spaceflight mission design and operations. DISCUSSION: For the framework and applications defined here to become operationally feasible, several limitations and gaps that remain to be addressed are presented with recommended future research and enabling technology advancement needs. Zero M, Klaus D, Arquilla K, Fanchiang C. Defining and measuring crewmember operational state for spaceflight operations. Aerosp Med Hum Perform. 2024; 95(12):919–929.
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