INTRODUCTION: The advent of autonomous automobiles raises new challenges for maintaining passenger safety and comfort. The challenge addressed here is how to predict and mitigate motion sickness when passengers read in a moving vehicle.METHODS: We utilized a car equipped with a commercial active suspension system developed for attenuating the transmission of road surface fluctuations to passengers. The system was used to reproduce, in a parked car, either the vibrations that would be experienced in a moving car equipped with a conventional suspension system (unmitigated ride) or the attenuated vibrations that would occur on the road with the active cancellation system engaged (mitigated ride). We evaluated the consequences of these two simulated ride conditions for reading performance, comfort, and evocation of motion sickness.RESULTS: Both ride conditions reduced the 0 to 0.8 Hz vibrations to below threshold for evoking motion sickness during passive exposure. Only the mitigated ride condition attenuated frequencies in the 0.8 to 8 Hz band where visual suppression of the vestibulo-ocular reflex is known to break down, and this condition also reduced the motion sickness induced by reading and increased reading comprehension and comfort relative to the unmitigated ride.DISCUSSION: The palliative effects of 0.8 to 8 Hz attenuation are discussed in terms of the different mechanisms underlying motion sickness evoked by reading in a vehicle versus mere exposure to vehicle motion without reading. Implications for ISO-2631 standards for human exposure to vibration are also discussed.DiZio P, Ekchian J, Kaplan J, Ventura J, Graves W, Giovanardi M, Anderson Z, Lackner JR. An active suspension system for mitigating motion sickness and enabling reading in a car. Aerosp Med Hum Perform. 2018; 89(9):822–829.