INTRODUCTION: Government space agencies and commercial spaceflight companies are seeking to expand human space exploration. Spaceflight can place considerable psychological stressors on humans, yet policies to support behavioral health in human spaceflight are still in their nascent stages. This article reviews international and domestic space policy relevant to behavioral health, as well as existing gaps in policy frameworks regarding the behavioral health of spaceflight crew and passengers. This article highlights behavioral health policy for human spaceflight as an emerging issue and suggests principles to guide the development of such policy moving forward.Morris NP. Behavioral health policy for human spaceflight. Aerosp Med Hum Perform. 2018; 89(12):1068–1075.