INTRODUCTION: Effects of exposure to hyperoxia (PiO₂ > 105 mmHg), normoxia (PiO₂ 95–105 mmHg) and hypoxia (PiO₂ < 95 mmHg) on simple and choice reaction performance tasks were evaluated.METHODS: Ten subjects performed simple and choice reaction time tests (SRT and CRT, respectively) at ground level for 40 min (20 min normoxic, 20 min hyperoxic, randomly assigned), 3048 m (10,000 ft) for 75 min (15 min hyperoxic, 60 min hypoxic), 4572 m (15,000 ft) for 60 min (15 min hyperoxic, 45 min hypoxic), and 6096 m (20,000 ft) for 35 min (15 min hyperoxic, 20 min hypoxic). SRT and CRT tests were also conducted at ground level 1 h after normoxic rest (recovery) to assess any recovery time effect on these psychomotor tasks.RESULTS: Total response time (TRT) significantly increased by 15 ms to 25 ms at all three altitudes for both the SRT and CRT tasks. At and below 4572 m, the performance changes were gradual over the duration of the exposures, whereas at 6096 m these changes were immediate. After 1 h, no performance decrement was measured. There was no statistical evidence that ground-level performance on these tasks was improved in hyperoxic vs. normoxic conditions.DISCUSSION: Results suggest mild decrements in reaction time due to hypoxia may occur as low as 3048 m (10,000 ft) while hyperoxia showed no positive effect on accuracy or reaction time at ground level or higher when performing simple and choice psychomotor reaction tasks.Dart T, Gallo M, Beer J, Fischer J, Morgan T, Pilmanis A. Hyperoxia and hypoxic hypoxia effects on simple and choice reaction times. Aerosp Med Hum Perform. 2017; 88(12):1073–1080.