parabolic flight studies 8 suggest that this initial pressure spike results from abrupt choroidal expansion within a rigid globe caused by a microgravity-induced venous stasis that inhibits the normal terrestrial gravity-dependent vortex venous drainage from the highly vascular choroid. The continued, sustained IOP increase during the first days of flight 2 may result from choroidal expansion, increased episcleral venous pressure, orbital pressure on the globe, or a combination of these mechanisms. This increased IOP gradually returns to normal during LDSF possibly