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, on Soyuz TM-14 and D2 Spacelab, IOP increased by 92% ( N = 1) and 114% ( N = 2) within 15–16 min in flight followed by a return to baseline within 7 h 18 min and 3–4 d, respectively. 3 Finally, Shuttle data from six missions ( N = 11) showed increases in IOP during flight day (FD) 1, with several measurements above the ocular hypertension threshold (21 mmHg) even as late as FD 9–10 with a return to baseline in flight or postflight. 16 Glaucoma, which afflicts 2.1% of Americans over age 40, is a pathologically elevated baseline IOP (normal IOP = 8