. Lowered shear stress, such as in reduced or low flow situations, has been associated with thrombosis via upregulated proinflammatory changes and prothrombotic markers, overriding the protective mechanisms, such as fibrinolysis, usually present with wall shear stress. 36 , 49 Additionally, this increase in inflammatory components upregulates the Von Willibrand factor and other coagulation factors, activating the coagulation cascade while promoting arterial atherogenic events. 8 It is currently unclear how weightlessness affects endothelial shear stress in both venous