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In pressurized aircraft, loss of cabin pressure at high altitude presents risks; in a small cockpit, the potential consequences of rapid decompression (RD) are grave, culminating in aircrew members’ loss of effectiveness, consciousness, and even life. 17 Although decompressions are rare, 9 the threat is amplified when the O 2 pressure in the inspired gas (P I O 2 ) is lower, when decompression reaches a higher altitude, and when the rate of decompression is higher. 22 Understanding the effects of low P I O 2 on hypoxia severity at terminal altitude