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The space environment imposes significant physiological, psycho-social, and cognitive loads on astronaut crew that likely impact crew performance during missions. To date, no systematic data collection has taken place to understand the effects of such loads on astronauts’ ability to retain trained knowledge and skills, and to transfer such knowledge and skills to novel situations. The present study is the first to systematically collect data on the effects of cognitive loads on long duration retention and transfer. To become an astronaut, several educational