Polycythemia is a state in which there are excessive red blood cells (RBC) in circulation. Etiologies of polycythemia can be categorized into primary and secondary causes. Primary polycythemia, known as polycythemia vera, is a disease of abnormally increased erythropoiesis by the bone marrow as a result of a genetic defect. Secondary polycythemia is mediated by erythropoietin (EPO) secretion. High altitude, smoking, lung diseases, and cardiovascular diseases are common causes of hypoxemia leading to EPO secretion and, consequently, secondary polycythemia