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Altitude chamber exposure of 15 men to repeated exertional hypobaria, representative of parachutist despatchers working at 25,000 ft (7620 m) altitude, enabled evaluation of the early pathophysiological responses to hyperoxic decompression stress. 6 Immediately postexposure, fivefold elevation of the proinflammatory cytokine interleukin-6 (IL-6) was accompanied by increased circulating neutrophils (mean 70%) and monocytes (37%). IL-6 increments appeared associated with severity of venous gas emboli bubble load. 5 , 6 Elevated levels of complement peptide C5a