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during exercise differed between MA and SL mice within three regions of the brain reward circuitry (core subregion of the nucleus accumbens, prefrontal cortex, and hypothalamus) to understand the motivation to engage in running at MA. We hypothesized that MA mice would be smaller and leaner and voluntarily run less compared to SL mice. We report that at MA, some physiological differences are apparent in the mouse model, suggesting that a better characterization of preclinical models in MA conditions are needed. METHODS Animals Adult C57BL/6 mice 3–4 mo of age