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(s) to address real-time technical limitations. 10 , 20 Human studies have been limited due to the need for subjects to remain as still as possible, often precluding the ability for dynamic AGSM. 6 A more interactive ultrasound capability may better provide dynamic vascular evaluation, feedback regarding effectiveness of straining, and even real-time cardiac assessment of hemodynamic response to hypergravity stressors. To our knowledge, real-time hand-held ultrasound for vascular and cardiac imaging has not been performed during human centrifuge exposure. Here we