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Vibrational effects of launch vehicles on liquid medications has been shown to result in excessive foaming. 4 Multiple ISS crews have filmed demonstrations of the challenges and solutions to overcoming lack of air-fluid separation levels for adequate liquid medication aspiration and administration in microgravity. 2 You realize the need to also consider expected side effects after administration, especially after the second dose. You turn to the FAA policy, which recommends DNIF for 48 hrs after vaccine administration, and review possible adverse reactions. 3